Stability of different subtypes of mild cognitive impairment among the elderly over a 2- to 3-year follow-up period.

نویسندگان

  • David A Loewenstein
  • Amarilis Acevedo
  • Brent J Small
  • Joscelyn Agron
  • Elizabeth Crocco
  • Ranjan Duara
چکیده

BACKGROUND/AIMS To investigate the longitudinal stability and progression of different subtypes of mild cognitive impairment (MCI) in older adults. METHODS We classified 217 individuals with no cognitive impairment (NCI), amnestic MCI (aMCI) based on a single test (aMCI-1) or multiple tests (aMCI-2+), nonamnestic MCI (naMCI) based on a single test (naMCI-1) or multiple tests (naMCI-2+), or amnestic + nonamnestic MCI (a+naMCI), using their baseline neuropsychological test scores, and performed annual follow-up evaluations for up to 3 years. RESULTS None of the subjects with aMCI-2+ reverted to normal during follow-up, with 50% of these subjects remaining stable and 50% worsening over time. Similarly, less than 20% of subjects with aMCI-2+ and a+naMCI reverted to NCI during the follow-up period, whereas 50% of aMCI-1 and 37% with naMCI-1 reverted to NCI during this same period. CONCLUSION Reversion to NCI occurs much more frequently when the diagnosis of MCI is based on the results of a single neuropsychological test than when it is based on the results of more memory tests. In epidemiological studies and clinical trials the diagnosis of MCI will likely be more stable if impairment on more than one test is required for amnestic and/or nonamnestic domains.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effectiveness of Cognitive Enhancement on Quality of Life in Elderly with Mild Cognitive Impairment

Introduction: Cognitive enhancement is a non-invasive brain method that has the potential to improve cognitive deficits in patients with symptoms of cognitive impairment such as mild cognitive impairment. Studies have not investigated the effectiveness of this method on people's quality of life. Therefore, the purpose of this study was to investigate the effectiveness of cognitive enhancement o...

متن کامل

Comparing the effectiveness of cognitive rehabilitation and compassion-based therapy on self-care behaviors of the elderly with mild cognitive impairment

Introduction: Recognizing the needs and health status of the elderly is one of the important issues of the society, and in order to empower and improve their conditions, new treatment solutions, rehabilitation and effective interventions should be researched. This study aimed to compare the effectiveness of cognitive rehabilitation and compassion-based therapy on self-care behaviors of the elde...

متن کامل

The Effect of Cognitive Rehabilitation on Cognitive State and Depression in Elderly People With Mild Cognitive Impairment in the Amir al-Muminin Nursing Home of Kerman City: A Pilot Study

Objectives: Aging is a sensitive period in life. Due to the increase in elderly people population and the possibility of mild cognitive impairment and depression in elderly people, prevention of Alzheimer's disease, improvement of cognitive status and depression are essential to increase the quality of life of elderly people. The aim of the present study was to investigate the effect of cogniti...

متن کامل

The Role of Neuropsychological Function Tests in Predicting Amnestic Mild Cognitive Impairment in the Elderly

Background: Various studies have documented age-related changes in cognitive abilities and neural basis. Objectives: To investigate the role of neuropsychological function tests in predicting amnestic mild cognitive impairment in the elderly. Materials & Methods: In this cross-sectional study with a correlational design, the study population included elderly people over 60 years old residing ...

متن کامل

Investigating the effectiveness of neuro-feedback on alpha and beta frequency bands in the elderly with mild cognitive impairment

Introduction: Aging is a process in which physiological and psychological changes, especially cognitive changes, are observed. The aim of the present study was to determine the effectiveness of neuro-feedback on the alpha frequency band and beta frequency band at points (F3, F4) in the elderly with mild cognitive impairment. Methods: For this purpose, in this semi-experimental research, 30 peo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Dementia and geriatric cognitive disorders

دوره 27 5  شماره 

صفحات  -

تاریخ انتشار 2009